PLA2

​​Prevalence and progression of subclinical cardiovascular disease assessed by 3D ultrasound of the carotid arteries and relation to platelet aggregation in individuals with type 2 diabetes.


​Persons with type 2 diabetes (T2D) have an excess risk of cardiovascular disease (CVD). There is an ongoing need to better identify high-risk individuals for therapy or prevention of CVD who are missed by current risk stratification methods based on simple clinical measures. Three-dimensional (3D) ultrasound of the carotid arteries is a new non-invasive, radiation-free and fast way to assess atherosclerosis. 3D ultrasound of the carotid arteries has previously been evaluated in the general population as an imaging-based biomarker for predicting atherothrombotic events. Detection of subclinical carotid or coronary atherosclerosis improved risk prediction and reclassification compared with conventional risk factors.

This study is designed with the primary aim to determine the prevalence of subclinical CVD among 500 asymptomatic individuals with T2D using 3D ultrasound to estimate plaque volume in the common and internal carotid arteries. Secondary, we will assess the platelet aggregation, endothelial dysfunction and vascular inflammation and relate these measures to the plaque volume. The study will provide new knowledge with the perspective to assess risk of CVD in people with T2D.

Aim

The primary aim to determine the prevalence of subclinical CVD among 500 asymptomatic individuals with T2D using 3D ultrasound to estimate plaque volume in the common and internal carotid arteries
Secondary, we will assess the platelet aggregation, endothelial dysfunction and vascular inflammation and relate these measures to the plaque volume.

Collaborators

Professor Henrik Sillesen, Department of Vascular Surgery, Rigshospitalet.
Professor Anne-Mette Hvas, Institute for Clinical Medicine, Aarhus University Hospital.



Responsible editor