motivation for studying metabolism is multi-fold. Due to its central
life-sustaining function metabolism is tightly homeostatically regulated. Accordingly,
its understanding may shed light on complex multi-level interactions within
biological systems and with the environment. Furthermore, the biochemical
networks underlying metabolism are the best characterized of any biological
of metabolism using emerging analytical and computational tools of metabolomics
may thus provide an opportunity for their quantitative analysis. From the
translational research perspective, derangements of metabolism play important
roles in the pathogenesis of most common diseases. These derangements may also
occur as co-morbidities underlying multiple apparently unrelated diseases.
System-level study of metabolism may thus identify common and specific pathways
and vulnerabilities underlying the pathogenesis of many diseases.
on systems medicine approach, where instead of focusing on each disease
individually, the aim is to account for the complex gene-environment,
socio-economic interactions and co-morbidities that lead to individual-specific
complex phenotypes. We are particularly interested in the identification of
disease vulnerabilities associated with different metabolic phenotypes and the
underlying mechanisms linking these vulnerabilities with the development of
specific disorders or their co-morbidities, with specific focus on obesity and
diabetes and their co-morbidities. Such in depth understanding of the metabolic
phenotypes in health and disease is crucial if one is to implement personalized
medicine. In addition to new knowledge on the disease etiology and
pathogenesis, our studies may discover novel biomarkers for early disease
detection as well as identify novel avenues for disease prevention or therapy.