Heart failure is a frequent,
forgotten and often fatal complication in diabetes. This study is designed with
the primary aim to identify subpopulations at high risk of developing
cardiovascular disease (CVD) among asymptomatic patients with type 2 diabetes
using 1) myocardial flow reserve; 2) atherosclerotic burden estimated as
coronary artery calcium score; and 3) systolic/diastolic dysfunction - all
assessed using hybrid Rb PET/CT imaging.
A total of 900 participants will be included.
Recruitment period is 4 years. Five and ten years after the baseline
examination we will perform register-based follow-up.
Despite significant therapeutic advances, cardiovascular disease remains the leading cause of mortality in patients with type 2 diabetes and is the largest contributor to the costs of diabetes. Improved cardiovascular risk stratification of patients with type 2 diabetes is therefore needed.
The primary aim is to identify subpopulations at high risk of developing cardiovascular disease among asymptomatic patients with type 2 diabetes.
Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet & Cluster for Molecular Imaging, and Steno Diabetes Center Sjælland, Denmark.