Kristine Færch

​Research Leader, professor
Clinical Prevention Research

Portrait photo of Kristine Færch​Contact

E-mail: Kristine.faerch@regionh.dk
Phone +45 30 91 30 61



Research area

Diagnosis and sub-classification

  • Addressing controversies in the diagnosis of pre-diabetes, gestational diabetes, and diabetes; 
  • Contributing with novel insights to the sub-classification of pre-diabetes and type 2 diabetes.

Pathophysiology and heterogeneity

  • Unravelling the complex pathophysiology of pre-diabetes and type 2 diabetes; 
  • Understanding the heterogeneity in disease development and in the response to interventions.

Etiology of pre-diabetes and type 2 diabetes

  • Exploring the role of the circadian clock and timing of diet, physical activity, and sleep in pre-diabetes and early development of type 2 diabetes; 
  • Understanding the role of genetics and lifestyle factors in the development of pre-diabetes, gestational diabetes, and type 2 diabetes.

Early prevention

  • Developing novel, feasible, interventions for early prevention of type 2 diabetes;
  • Testing the effect of preventive interventions in individuals at high risk of developing type 2 diabetes and cardiovascular disease.

Current research

The PRE-D Trial

Aim: To compare the efficacy of three short-term glucose-lowering interventions (exercise, metformin and dapagliflozin) on glycaemic variability in overweight or obese men and women with elevated diabetes risk (haemoglobin A1c (HbA1c) 39–47 mmol/mol). Secondary aims are to investigate the effects of the interventions on body composition and cardiometabolic risk factors.

Collaborators: Marit E. Jørgensen (SDCC), Frederik Persson (SDCC), Mathias Ried-Larsen (Rigshospitalet), Kristian Karstoft (Rigshospitalet). The trial is sponsored by the Novo Nordisk Foundation and Astra Zeneca.

The RESET Trial

Aim: To examine effects of time-restricted eating on change in body weight, behaviour and metabolism in individuals at high risk of type 2 diabetes. 
Collaborators: Researchers at SDCC and at the University of Copenhagen; Christina Brock at Aalborg University; Satchin Panda at Salk Institute for Biological Studies, La Jolla, CA; Graham Finlayson at University of Leeds, UK. 

The PRESET study

Aim: To evaluate methods for measuring gastrointestinal transit time and food reward and preferences in healthy individuals.

Collaborators: Researchers at SDCC and at the University of Copenhagen; Christina Brock at Aalborg University; Satchin Panda at Salk Institute for Biological Studies, La Jolla, CA; Graham Finlayson at University of Leeds, UK.

The Whitehall II study

Aim: To conduct epidemiological analyses of the relationship of pre-diabetes with lifestyle factors and development of diabetes and cardiovascular disease.
Collaborators: Eric Brunner (UCL, London, UK), Mika Kivimäki (UCL, London, UK), Adam Tabak (Semmelweis University, Hungary), Daniel R. Witte (Aarhus University, Aarhus), Adam Hulman (Aarhus University, Aarhus)


The ADDITION-PRO study

Aim: To study the role of incretin hormones and other measures of glucose metabolism in the early development of type 2 diabetes and cardiovascular disease. 

Collaborators: Marit E. Jørgensen and Dorte Vistisen, SDCC; Daniel R. Witte, Aarhus University; Annelli Sandbæk, SDCA; Jens Juul Holst, University of Copenhagen, etc. 







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