Sara Juul Mansachs

MD, PhD student,
Transltional Type 1 Diabetes Research

Research area

My PhD project focuses of minor autoantibodies in type 1 diabetes (T1D) and their association with disease debut and development.

Testing of type 1 diabetes (T1D) minor autoantibodies
Examining how many Danish T1D patients have minor autoantibodies.

Testing of T1D minor autoantibodies in relatives
Investigating if T1D siblings, who are in high risk of T1D, have minor autoantibodies.

Stratifying of minor autoantibodies according to T1D susceptible genes and clinical parameters
Investigating if there is a correlation between minor autoantibodies, T1D susceptible genes and the severity of diabetic ketoacidosis, hypoglycemic events and long term outcome.

Current research

Autoantibodies affecting T1D onset, remission phase and long-term outcome

Aim: T1D has a preclinical stage identified by autoantibodies. Most children with T1D have multiple autoantibodies. New minor autoantibodies have been investigated. These are autoantibodies against Neuropeptide Y (NPY), VAMP2 and SNARE. This project will give an in depth characterization of minor autoantibodies and elucidate their impact of the prediabetic and symptomatic stages of T1D.

Collaborators: Jesper Johannesen, Åke Lernmark

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