My research focuses on exploring the role of repeat elements, non-coding RNAs and distal regulatory elements in type 1 diabetes (T1D) using computational biology methods. I am intergrating and analyzing large datasets such as RNA-sequencing data and genome-wide association scans (GWAS).
Non coding RNAs and repeat elements in type 1 diabetes
Various classes of non-coding RNAs including circRNAs and long non-coding RNAs that may play a role for T1D development are investigated in human pancreatic islets.
Genotype-to-phenotype mapping in type 1 diabetes
Next-generation sequencing and GWAS data are integrated to identify potential functional disease-associated single nucleotide polymorphisms.
Regulatory elements in type 1 diabetes loci
Aim: To identity aberrantly-regulated non-coding RNAs in human pancreatic islets following exposure to cytokines.