Combination treatment with a GLP-1 analogue and a SGLT-2-inhibitor in participants with type 2 diabetes and albuminuria to demonstrate a beneficial effect on renal parameters.
Diabetes and oxidative stress
The effect of treatment with incretins on oxidative stress in participants with type 2 diabetes.
The aim of the study is to investigate if a stepwise initiation of semaglutide or placebo added to ongoing empagliflozin therapy would complement or have an additive effect on renal parameters.
Collaborators: Novo Nordisk A/S.
The aim of the study is to demonstrate if treatment with liraglutide or sitagliptin reduces oxidative stress measured as urinary excretion of 8-oxodG and 8-oxoGuo.
Collaborators: Department and Laboratory of Clinical Pharmacology, Bispebjerg Frederiksberg Hospitals, Rigshospitalet.