Individuals with overweight and obesity are at increased risk of type 2 diabetes. Current prevention and treatment strategies include physical activity and energy restricted diets which are difficult to maintain for most individuals. Animal studies and a few small human studies have suggested promising effects of time-restricted eating on weight loss and cardiometabolic health.
The aim of the RESET study is to examine the effectiveness and feasibility of 13 weeks time-restricted eating on behavior and metabolism in individuals at high risk of type 2 diabetes.
100 adults with obesity or overweight in combination with pre-diabetes will be randomized to 13 weeks of time-restricted eating (eating window: 10 hours/day) or habitual lifestyle. Maintenance will be assessed at a follow-up visit after 26 weeks.
Change in body weight.
Secondary outcomes include but are not limited to changes in:
- Body composition
- Glucose metabolism
- Gastrointestinal transit times
- Appetite regulation
- Conscious and non-conscious food-related behavior
- Blood pressure and heart rate variability
- Energy expenditure
- Physical activity
- Respiratory and glycolytic capacities
- Proteomics and metabolomics
- Self-rated health
Motivation, feasibility and sustainability will be assessed using qualitative methods.
- Type 1 Biology and Health Promotion, SDCC
- University of Copenhagen
- Aalborg University Hospital
- University of Leeds, UK
- Salk Institute of Biological Studies, CA, USA
- iMotions A/S