Cathepsins in type 1 diabetes
The gene encoding the lysosomal cysteine protease cathepsin H (CTSH) is a type 1 diabetes (T1D) candidate gene located at the susceptibility locus on chromosome 15q25.1. The project aims at understanding the roles of CTSH and other cathepsins for beta cell function and T1D risk.
Metabolomics and autoantibody development in individuals at high risk for type 1 diabetes
The project seeks to identify risk metabolomic profiles for autoimmunity and type 1 diabetes. By further investigating the relationship of these metabolomic profiles with other established genetic and environmental risk factors for type 1 diabetes, we hope to contribute to the unraveling of this complex immunologic/metabolic disease and highlight potential new therapeutic targets.
Non-coding RNAs in breast milk and their potential role in type 1 diabetes
Breastfeeding is associated with a reduced risk of type 1 diabetes (T1D) for the infant. As breastmilk contain immune-modulatory microRNAs (miRNAs) – key regulators of gene expression – we wish to identify and compare the miRNA levels in breastmilk from healthy control and T1D lactating mothers. The functions of miRNAs found to be aberrantly expressed in breastmilk from T1D mothers will be tested in cellular experiments using human monocytic THP-1 cells.
Src kinase-associated phosphoprotein 2 (SKAP2) in type 1 diabetes
The gene encoding Src kinase-associated phosphoprotein 2 (SKAP2) located on Chr 7 is a type 1 diabetes (T1D) candidate gene. The project seeks to clarify if SKAP2 affects T1D risk by modulating beta cell fragility.
INNODIA (an innovative approach towards understanding and arresting type 1 diabetes) is an international consortium consisting of academic institutions including SDCC, clinics, patient organizations, partners and enterprises.