Diabetic autonomic and sensimortor neuropathy. New risk markers for early signs of development of neuropathy.
Trials of different treatment modalities to prevent or delay progression of diabetic neuropahty.
Investigation of the association between neuropathy and complications eg. brainfunction, foot complication and heart disease.
1. Whitehall II study
Aim: The association between autonomic function and inflammatory markers, beta cell function and cardiovascular disease.
Partners: University City College London, Center of diabetes research, Düsseldorf university.
Aim: The reversibility of autonomic and peripheral neuropathy in type 1 diabetes patents.
Partners: NovoNordisk Foundation, Joslin Diabetes Center (USA), University Medical Center Groningen (Holland), Folkhälsan Helsinki (Finland).
Aim: The effect of metformin on peripheral and autonomic neuropathy.
Partners: dept. endocrinology. Herlev Hospital, the research unit at Hillerød Hospital.
4. The young study
Aim: Prevalence of neuropathy in young type 1 diabetes patients and risk factors hereto.
Partners: dept. endocrinology Herlev Hospital Heidelberg University hospital.
5. Metformin and neuropati
Aim: Acute effect on markers of autonomic neuropathy in type 2 diabetes patients.
Partners: Center for diabetes research Gentofte Hospital.
6. Diabetes and neurovascular coupling
Aim: investigating the association between autonomic dysfunction and brain function.
Partners: NEXs Copenhagen University, Aalborg University.
7. Diabetic neuropathy and exercise
8. Diabetic gastropareses and neuropathy
Aim: Investigate the safety and efficacy of exercise in type 1 diabetes patients with autonomic neuropathy.
Partners: Shefield University Hospital, Dept. of research Hillerød Hospital, Steno Diabetes Center Århus.
Aim: Investigating the association between gastropareses and signs of neuropathy in the gastrointestinal mucosa and sign of neuropathy and gastrointestinal function.
Testing the efficacy of a novel surgical treatment method for gastroparesis (G-POEM).
Partners: Center for diabetes research Gentofte Hospital, Dept. of nuclear medicine Rigshospitalet, Dept. of Surgery, Hvidovre Hospital.
9. Exploring novel risk markers and potential treatment targets for neuropathic pain in type 1 diabetes
Aim: To investigate pathological changes to nerve fibres in skin biopies in patients with painful neuropathy and type 1 diabetes.
Partners: Steno Diabetes Center Aarhus and Odense, Denmark. Heidelberg University Hospital.
10. Genetic risk factors for diabetic neuropathy in Greenland and Denmark
Aim: To investigate new genetic risk factors for diabetic neuropathy in Greenland and Denmark.
Partners: Steno Diabetes Center Aarhus. Metabolisme center, Panum, Denmark.
11. New refference values for cardiovascular autonomic neuropathy (CAN)
Aim: Generate new reference values for CAN based on a healthy Danish cohort.
Partners: Steno Diabetes Center Aarhus og Sealand. Lolland-Falster study group.
Aim: To study the efficacy of treatment with probiotics on diabetic nephropathy.
Partners: DSM, Copenhagen Biocare, Metabolisme Center, Panum.