Ninna Senftleber

​PhD-student,
Clinical Epidemiology

​Contact

E-mail: ninna.senftleber@regionh.dk

Research area

1. Cardiovascular diseases (CVD) in Greenlandic Inuit: Assessing the effect of n-3 polyunsaturated fatty acids on CVD risk, using epidemiological data analysis on data from the Greenlandic Population Survey.

2. Effects of diet-gene interactions on erythrocyte membrane fatty acid concentrations in Greenlandic Inuit.

Current research

1. Omega-3 fatty acids and risk of first cardiovascular event in Greenlandic Inuit: A prospective cohort study. 

Aim: to assess if there is an association between the concentration of eicosapentaenoic acid and docosahexaenoic acid in the erythrocyte membrane (omega-3 index) and CVD risk in Inuit.

Collaborators 

  •  Marit Eika Jørgensen, Clinical Epidemiology Research, Steno Diabetes Center Copenhagen
  • Anders Albrechtsen, Bioinformatics Centre, Department of Biology, University of Copenhagen
  • Lotte Lauritzen, Department of Nutrition, Exercise and Sports, University of Copenhagen

 

2. Interactions between genetic variants of CPT1A, FADS2, and FADS3 and traditional food intake and n-3 fatty acids on erythrocyte fatty acids in Greenlandic Inuit

Aim: to assess if an interaction exists between the rs80356779 (CPT1A), rs174570 (FADS2), and rs7115739 (FADS3) variants and the intakes of traditional diet and VLC n-3 PUFAs on the erythrocyte membrane concentrations of selected fatty acids in Greenlandic Inuit. Erythrocyte fatty acid levels of specific interest are the fatty acids that previously have been found to be strongly associated with the genetic variants.

Collaborators 

  •  Marit Eika Jørgensen, Clinical Epidemiology Research, Steno Diabetes Center Copenhagen
  • Anders Albrechtsen, Bioinformatics Centre, Department of Biology, University of Copenhagen
  • Nita Forouhi and Fumiaki Imamura, Nutrition Epidemiology, Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine.


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