Six studies with data from more than 5,500 individuals.  

Clinical exams, patient-reported outcomes, lab results.  

Diagnostic imaging, omics, and physiological function assessments in many studies.  

Blood and urine samples in biobanks available for further research for most studies.  

Potential linkage to Danish national health registries for outcome analysis.   

Design: Randomized, double-blind, placebo-controlled, parallel, single-center study.  

Year of completion: 2023.  

Participants: 60 adult individuals with type 2 diabetes and albuminuria, recruited from Steno Diabetes Center Copenhagen, Denmark.  

Aim: To investigate whether combined treatment with empagliflozin and semaglutide can reduce urinary albumin-creatinine ratio (UACR) compared to treatment with empagliflozin alone in individuals with type 2 diabetes and albuminuria.  

Data types: Clinical data including measurements of UACR, glomerular filtration rate (GFR), 24-hour blood pressure, glycated hemoglobin (HbA1c), body weight, and plasma renin and aldosterone levels.  

Biobank for future research: Yes.  

Possibility for linkage to other databases: Can be linked to Danish National registers and electronic patient records, short follow-up time.  

Design: Cross-sectional observational study with prospective follow-up for cardiovascular events over 5 years. Annual visits were conducted to collect NT-proBNP, urine samples, EKG, plasma, and serum.  

Year of completion: 2012.  

Participants: 200 adult individuals with type 2 diabetes and micro- or macroalbuminuria, recruited from Steno Diabetes Center, without symptoms or prior diagnosis of heart disease.  

Aim: To investigate the prevalence of asymptomatic cardiovascular disease in patients with type 2 diabetes and albuminuria, using NT-proBNP levels as a screening tool for undiagnosed cardiovascular disease.  

Data types: Clinical data including NT-proBNP levels, coronary calcium score, echocardiography, coronary angiography, SPECT scanning, MRI for brain vascular changes, and cardiovascular and kidney outcomes at approximately 5 years.  

Biobank for future research: Yes, including urine, plasma, and serum samples.  

Possibility for linkage to other databases: Can be linked to Danish National registers and electronic patient records.  

Design: Cross-sectional study with a 5-year prospective follow-up.  

Year of completion: 2011.  

Participants: 676 patients with type 1 diabetes, divided into three groups: 304 with normoalbuminuria, 152 with microalbuminuria, and 179 with macroalbuminuria, along with 51 non-diabetic control participants.  

Aim: To investigate the 24-hour central and peripheral blood pressure profile in patients with type 1 diabetes and its relation to autonomic neuropathy and diabetic nephropathy.   

Data types: Clinical data include 24-hour blood pressure, ecg, pulse wave velocity, laboratory measures (e.g., HbA1c, lipid profile, renal function), and autonomic neuropathy assessments.  

Biobank for future research: Yes, including blood and urine samples.  

Possibility for linkage to other databases: Can be linked to Danish National registers and electronic patient records.  

Reference: https://doi.org/10.2337/dc12-0850  https://doi.org/10.2337/dc12-0850

Design: Cross-sectional observational study.  

Year of completion: 2016  

Participants: 2,255 individuals with type 1 or type 2 diabetes recruited from Steno Diabetes Center Copenhagen, Denmark.  

Aim: To investigate the role of plasma vitamin D levels in the development and progression of acute and chronic complications in patients with diabetes, with a focus on bone, cardiovascular, and kidney disease.   

Data types: Clinical data from patient records, plus blood and urine samples. Key biomarkers include vitamin D, renal function, and cardiovascular risk markers.  

Biobank for future research: Yes, blood and urine samples.  

Possibility for linkage to other databases: Can be linked to Danish National registers and electronic patient records.