DIA-HEART

​​Deep phenotyping of the heart with advanced imaging modalities in type 2 diabetes – implications for pathophysiology and prognosis.

Heart failure is a frequent, forgotten and often fatal complication in diabetes. This study is designed with the primary aim to identify subpopulations at high risk of developing cardiovascular disease (CVD) among asymptomatic patients with type 2 diabetes using 1) myocardial flow reserve; 2) atherosclerotic burden estimated as coronary artery calcium score; and 3) systolic/diastolic dysfunction - all assessed using hybrid Rb PET/CT imaging.

A total of 900 participants will be included. Recruitment period is 4 years. Five and ten years after the baseline examination we will perform register-based follow-up.

Despite significant therapeutic advances, cardiovascular disease remains the leading cause of mortality in patients with type 2 diabetes and is the largest contributor to the costs of diabetes. Improved cardiovascular risk stratification of patients with type 2 diabetes is therefore needed.

Aim

The primary aim is to identify subpopulations at high risk of developing cardiovascular disease among asymptomatic patients with type 2 diabetes.

Collaborators

Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet & Cluster for Molecular Imaging, and Steno Diabetes Center Sjælland, Denmark.



Responsible editor