Aim

The aim of the RESET study is to examine the effectiveness and feasibility of 13 weeks time-restricted eating on behavior and metabolism in individuals at high risk of type 2 diabetes.

Design

100 adults with obesity or overweight in combination with pre-diabetes will be randomized to 13 weeks of time-restricted eating (eating window: 10 hours/day) or habitual lifestyle. Maintenance will be assessed at a follow-up visit after 26 weeks.

Primary outcome

Change in body weight.

Secondary outcomes include but are not limited to changes in:

• Body composition
• Glucose metabolism
• Gastrointestinal transit times
• Appetite regulation
• Conscious and non-conscious food-related behavior
• Blood pressure and heart rate variability
• Energy expenditure
• Physical activity
• Sleep
• Microbiome
• Respiratory and glycolytic capacities
• Proteomics and metabolomics
• Self-rated health

Motivation, feasibility and sustainability will be assessed using qualitative methods.

Collaborators

• Type 1 Biology and Health Promotion, SDCC
• University of Copenhagen
• Aalborg University Hospital
• University of Leeds, UK
• Salk Institute of Biological Studies, CA, USA
• iMotions A/S