RESET study

​​Effect of time-restricted eating on behaviour and metabolism in overweight individuals at high risk of type 2 diabetes.


The aim of the RESET study is to examine the effectiveness and feasibility of 13 weeks time-restricted eating on behavior and metabolism in individuals at high risk of type 2 diabetes.


100 adults with obesity or overweight in combination with pre-diabetes will be randomized to 13 weeks of time-restricted eating (eating window: 10 hours/day) or habitual lifestyle. Maintenance will be assessed at a follow-up visit after 26 weeks.

Primary outcome

Change in body weight.

Secondary outcomes include but are not limited to changes in:

  • Body composition
  • Glucose metabolism
  • Gastrointestinal transit times
  • Appetite regulation
  • Conscious and non-conscious food-related behavior
  • Blood pressure and heart rate variability
  • Energy expenditure
  • Physical activity
  • Sleep
  • Microbiome
  • Respiratory and glycolytic capacities
  • Proteomics and metabolomics
  • Self-rated health

Motivation, feasibility and sustainability will be assessed using qualitative methods.


  • Type 1 Biology and Health Promotion, SDCC
  • University of Copenhagen
  • Aalborg University Hospital
  • University of Leeds, UK
  • Salk Institute of Biological Studies, CA, USA
  • iMotions A/S

Responsible editor