Background and aim
Sucrose intolerance is in general rare; however, it is a common condition in Greenland and other Inuit populations. Here, a genetic variant in the sucrase-isomaltase (SI) gene causes complete loss of enzyme function, hindering digestion of sucrose partly starch. The variant was recently associated with a metabolically healthier phenotype.
Including Greenlandic individuals with genetically inherited sucrase-isomaltase deficiency (cases) and controls, we are assessing differences between the two groups on:
1. Food- and taste preferences.
2. Habitual dietary intake of sucrose, starch and macronutrients.
Furthermore, we are assessing how cases and controls respond to a western diet high in carbohydrate and to a traditional diet high in protein and fat with respect to:
3. Carbohydrate metabolism
4. Gut microbiota
Collaborators
The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
Department of Food Science, University of Copenhagen
Steno Diabetes Center Greenland
Funding
Start date 01-07-2021
End date 30-06-2024